ORCID: https://orcid.org/0000-0001-5304-2026

45)         “Starting and Stopping RNA Polymerase III Transcription on Single-stranded DNA Oligonucleotides,” Lama, L. and Ryan, K.* RNA. Oct 2022; 28 (10) (epub July 2022). doi:10.1261/rna.078981.121

44)       “Conformational sensing by a mammalian olfactory receptor,” M.T. Liu, M. Na, Y. Li, M. Biscoe and K. Ryan*, Chemistry-A European Journal, 2020, Vol. 26(50), pp 11345-11655 (September 4, 2020 issue) https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/chem.202003590 or https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/chem.202001390

43)       “Small RNA-seq: The RNA 5’ end ligation problem and a method to circumvent it,” L. Lama, J. Cobo, D. Buenaventura, and K. Ryan,* Journal of Biological Methods 2019, Vol. 6(1) e108  http://www.jbmethods.org/jbm/article/view/269

42)        Single-neuron comparison of the olfactory receptor response to deuterated and non-deuterated odorants, Mihwa Na, Min Ting Liu, Minh Q. Nguyen and Kevin Ryan*, ACS Chemical Neuroscience. DOI: 10.1021/acschemneuro.8b00416, Published Oct. 22, 2018. https://pubs.acs.org/doi/full/10.1021/acschemneuro.8b00416

41)          “Carbon chain shape selectivity by the mouse olfactory receptor OR-I7,” Min Ting Liu, Jianghai Ho, Jason Liu, Radhanath Purakait, Uriel N. Morzan, Lucky Ahmed, Victor S. Batista, Hiroaki Matsunami,* and Kevin RyanOrganic and Biomolecular Chemistry, 2018, 16, 2541-2548. PMCID:PMC6067823. https://pubs.rsc.org/en/content/articlepdf/2018/ob/c8ob90054j

40)          “Optimizing In Vitro Pre-mRNA 3′ Cleavage Efficiency: Reconstitution from Anion-Exchange Separated HeLa Cleavage Factors and from Adherent HeLa Cell Nuclear Extract,” Na, M., Valente, S. and Ryan, K.*Methods in Molecular Biology (2017) Eukaryotic Transcription and Post-Transcription Gene Expression Regulation Vol. 1507, Chapter 14 (Springer Publishing ISBN 978-1-4939-6516-8) November 2016 https://pubmed.ncbi.nlm.nih.gov/27832541

39)          “RNA polymerase III initiation on coligo DNA templates containing loops of variable sequence, size and nucleotide chemistry,” Joy Patel, Lodoe Lama, Niklas Hoffmann, Jose Cobo Christoph Müller and Kevin Ryan,* Gene (2016) 612:49-54 Epub September 2, 2016, http://dx.doi.org/10.1016/j.gene.2016.09.001

38)          “An investigation into the role of ATP in the mammalian pre-mRNA 3’ cleavage reaction,” Khleborodova, A., Nagre, N., Pan, X., and Ryan, K.* Biochimie 2016 (April 6) 125: 213-222. PMID 27060432; PMCID not yet available. DOI: 10.1016/j.biochi.2016.04.004

37)        “Adenylylation of small RNA sequencing adapters using the TS2126 RNA ligase I,” Lodoe Lama and Kevin Ryan,* RNA 2016 Jan; 22(1):155-61. DOI: 10.1261/rna.054999.115. Epub 2015 Nov 13. PMID: 26567315; PMCID: PMC4691829 https://rnajournal.cshlp.org/content/early/2015/11/13/rna.054999.115.abstract

36)          Aldehyde Recognition and Discrimination by Mammalian Odorant Receptors via Functional Group-Specific Hydration Chemistry, Li Y, Peterlin Z, Ho J, Yarnitzky T, Liu MT, Fichman M, Niv MY, Matsunami H, Firestein S,* Ryan K.* ACS Chemical Biology. (2014) Vol. 9 (11): 2563-71; PMID: 25181321; PMCID: PMC4245160.  https://pubs.acs.org/doi/abs/10.1021/cb400290u

35)          “New insights into the promoterless transcription of DNA coligo templates by RNA polymerase III,” Lodoe Lama, Christine I. Seidl, and Kevin Ryan,* 2014 Transcription, Vol. 5, Issue 2. Published online 27 January 2014; https://www.tandfonline.com/doi/abs/10.4161/trns.27913

34)          “Analysis of RNA processing reactions using cell free systems: 3′ end cleavage of pre-mRNA substrates in vitro,” Joseph Jablonski, Mark Clementz, Kevin Ryan and Susana T. Valente,* J Vis Exp. (JoVE), 2014 May 3, (87). DOI: 10.3791/51309. http://www.ncbi.nlm.nih.gov/pubmed/24835792

33)          “Structurally diverse low molecular weight activators of the mammalian pre-mRNA 3’ cleavage reaction,” Min Ting Liu, Nagaraja N. Nagre, and Kevin Ryan,* Bioorganic and Medicinal Chemistry 2013 Jan 15; 22(2):834-41. DOI: 10.1016/j.bmc.2013.12.006. Published online 2013 Dec. 15. PMID: 24373842 https://www.sciencedirect.com/science/article/pii/S0968089613010006

32)          “Circularized synthetic oligodeoxynucleotides serve as promoterless RNA polymerase III templates for small RNA generation in human cells,” C.I. Seidl, L. Lama and K. Ryan*, 2012 Nucleic Acids Research2013 41 (4): 2552-2564. DOI: 10.1093/nar/gks1334 First published online: December 28, 2012. PMCID: PMC3575851  https://academic.oup.com/nar/article/41/4/2552/2414788

31)          “Circular Single-Stranded Synthetic DNA Delivery Vectors for microRNA,” C. Seidl and K. Ryan*, PLoS One, Feb. 2011 6(2): e16925. DOI:10.1371/journal.pone.0016925. PMCID: PMC3040211 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0016925

30)          “Discrimination of saturated aldehydes by the rat I7 olfactory receptor,” M.D. Kurland, M.B. Newcomer, Z. Peterlin, K. Ryan, S. Firestein, and V.S. Batista*, Biochemistry, 2010, 3, 49(30):6302-4. PMCID: PMC2912408. https://www.ncbi.nlm.nih.gov/pubmed/20608641

29)          “Molecular Shape and the Sense of Smell,” Kevin Ryan* and Xiaozhou P. Ryan, book chapter in The 2010 McGraw-Hill Yearbook of Science and Technology, 2010, 243-245. https://www.accessscience.com/content/molecular-shape-and-the-sense-of-smell/YB100116

28)        “Small-molecule activators of pre-mRNA 3’ cleavage,” Kevin Ryan*, Asya Khleborodova, Jingyi Pan, and Xiaozhou P. Ryan RNA, 2009 15, 3, 483-492. PMCID: PMC2657006. https://rnajournal.cshlp.org/content/15/3/483.full?sid=789867ea-362a-4267-bf96-7ed87a3160e5

27)          “The Importance of Odorant Conformation to the Binding and Activation of a Representative Olfactory Receptor,” Zita Peterlin, Yadi Li, Grant Sun, Rohan Shah, Stuart Firestein, and Kevin Ryan* Chemistry and Biology, 2008 15, 12, 1317-1327. https://www.cell.com/cell-chemical-biology/fulltext/S1074-5521(08)00419-5

26)         “Finishing Touches: Post-Translational Modification of Protein Factors Involved in Mammalian pre-mRNA 3’ End Formation,” Kevin Ryan* and David L.V. Bauer, Int. J. Biochem. & Cell Bio. 2008 40, 11,2384-2396. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2548416/?tool=pubmed

25)          “Pre-mRNA 3’ Cleavage is Reversibly Inhibited in Vitro by Cleavage Factor Dephosphorylation,” Kevin Ryan*, RNA Biology, 2007, 4 (1) 26- 33. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851251

24)          “Symplekin and xGLD-2 are required for CPEB-mediated cytoplasmic polyadenylation,” Daron Barnard, Kevin Ryan, James L. Manley and Joel Richter*, Cell, 2004, 119 (5), 641-51. https://www.ncbi.nlm.nih.gov/pubmed/15550246

23)          “Evidence that polyadenylation factor CPSF-73 is the mRNA 3′ processing endonuclease,” Kevin Ryan, Olga C. Calvo and James L. Manley*, RNA, 2004, 10 (4):565-73. https://rnajournal.cshlp.org/content/10/4/565.long

22)          “Requirements of the RNA Polymerase II C-Terminal Domain for Reconstituting pre-mRNA Cleavage,” Kevin Ryan, Kanneganti G.K. Murthy, Syuzo Kaneko and James L. Manley*, Molecular and Cellular Biology, 2002, 22, 6, 1684-1692. https://mcb.asm.org/content/22/6/1684.full?view=full&pmid=11865048

21)          “Phosphorylation of CPEB by Eg2 Mediates the Recruitment of CPSF into an Active Cytoplasmic Polyadenylation Complex,” Raul Mendez, Kanneganti G.K. Murthy, Kevin Ryan, James L. Manley and Joel D. Richter,* Molecular Cell, 2000, Nov; 6(5):1253-9. https://www.ncbi.nlm.nih.gov/pubmed/11106762

20)          “A Synthetic Receptor Motif Designed for Extended Peptide Conformations,” Kevin Ryan, Leland Gershell, and W. Clark Still,*Tetrahedron2000, 21, 3309-3318.    https://www.sciencedirect.com/science/article/pii/S0040402000002520

19)          “Inhibition of Gene Expression in Human Cells Through Small Molecule-RNA Interactions,” Seongwoo Hwang, Natarajan Tamilarasu, Kevin Ryan, Ikramul Huq, W. Clark Still, and Tariq M. Rana,* Proceedings of the National Academy of Sciences, USA, 1999, 96, 23, 12997-13002. https://www.pnas.org/content/96/23/12997.full

18)          “Construction of Sequence-Selective Peptide Receptors from Conformationally Restricted Eta– and Theta– Amino Acids,” Kevin Ryan and W. Clark Still,* Bioorganic and Medicinal Chemistry Letters, 1999, 9, 2673-2678. https://www.ncbi.nlm.nih.gov/pubmed/10509914

17)          “Triplex-Directed Self-Assembly of an Artificial Sliding Clamp on Duplex DNA,” Kevin Ryan and Eric T. Kool,* Chemistry And Biology, 1998, 5:59-67.  Also featured on the cover of this issue. https://www.ncbi.nlm.nih.gov/pubmed/9495829?dopt=Abstract

16)          “Synthesis and Reactivity of Pyrrolo[3,2,E]indole: Removal of an N-bom Group From an Unactivated Indole,” John E. Macor,* James T. Forman, Ronald J. Post and Kevin Ryan, Tetrahedron Letters, 1997, 38, 10, 1673-1676. https://www.sciencedirect.com/science/article/pii/S0040403997001986

15)          “A Direct Synthesis of 3-(Pyrrolidin-3-yl)indoles for Use As Conformationally Restricted Analogs of Tryptamines” John E. Macor, David H. Blank, Kevin Ryan, Ronald J. Post, Synthesis 1997, 443-449. https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-1997-1214

14)          “Rolling Circle DNA Synthesis: Small Circular Oligonucleotides as Efficient Templates for DNA Polymerases,” Dongyu Liu, Sarah L. Daubendiek, Martin A. Zillman, Kevin Ryan, and Eric T. Kool,* Journal of the American Chemical Society, 1996, 118, 1587-94. https://www.ncbi.nlm.nih.gov/pubmed/20830216

13)          “Rolling-Circle RNA Synthesis: Circular Oligonucleotides as Efficient Substrates for T7 RNA Polymerase,” Sarah L. Daubendiek, Kevin Ryan, and Eric T. Kool,* Journal of the American Chemical Society, 1995, 117, 7818-7819. https://pubs.acs.org/doi/abs/10.1021/ja00134a032

12)          “5-(3-Nitropyrid-2-ylamino)indoles: Novel Serotonin Agonists with Selectivity for the 5-HT1D Receptor. Variation at C3 of the Indole Template Leads to Increased 5-HT1D Receptor Selectivity,” John E. Macor,* David H. Blank, Carol B. Fox, Lorraine A. Lebel, Michael E. Newman, Kevin Ryan, Ronald J. Post, Anne W. Schmidt, David W. Shullz, and B. Kenneth Koe, Journal of Medicinal Chemistry, 1994, 37, 2509. https://www.ncbi.nlm.nih.gov/pubmed/8057297

11)          “The Synthesis of a Conformationally Restricted Analog of the Neurotransmitter, Serotonin with Reduced Basicity,” John E. Macor and Kevin Ryan, Heterocycles, 1994, 37, 1447. https://www.heterocycles.jp/newlibrary/payments/form/05480/PDF

10)          “A Simple Synthesis of 5-Amino-3-(2-dimethylaminoethyl) indole[5-amino-N,N-dimethyl-tryptamine],” John E.Macor,* Ronald J.Post, and Kevin Ryan, Synthetic Communications, 1993, 23, 65. https://www.tandfonline.com/doi/abs/10.1080/00397919308020402

9)            “Synthesis and Serotonergic Pharmacology of the Enantiomers of 3-[(N-Methylpyrrolidin-2-yl)methyl]-5-methoxy-1H-indole: Discovery of Stereogenic Differentiation in the Aminoethyl Side Chain of the Neurotransmitter Serotonin,” John E. Macor ,* James Blake, Carol B. Fox, Celeste Johnson, B. Kenneth Koe, Lorraine A. Lebel, Jean M. Morrone, Kevin Ryan, Anne W. Schmidt, David W. Schulz, and Stevin H. Zorn, Journal of Medicinal Chemistry,1992, 35, 4503-4505. https://www.ncbi.nlm.nih.gov/pubmed/1447752

8)            “A Synthesis of 5-Carboxamidopyrrolo[3,2-b]pyridine,” John E. Macor*, Ronald Post and Kevin Ryan, Journal of Heterocyclic Chemistry, 1992, 29, 1465-1467. https://onlinelibrary.wiley.com/doi/abs/10.1002/jhet.5570290616

7)            “Synthesis of a Conformationally Restricted Analog of the Anti-Migraine Drug Sumatriptan,” John E. Macor,* David H. Blank, Ronald J.Post and Kevin Ryan, Tetrahedron Letters, 1992, 33, 52, 8011-8014. https://www.sciencedirect.com/science/article/pii/S0040403900747034

6)            “The Synthesis of Pyrano[3,2-e]indoles and Pyrano[2,3-f]indoles as Rotationally Restricted Phenolic Analogs of the Neurotransmitter Serotonin,” John E. Macor*, Kevin Ryan, and Michael E. Newman, Tetrahedron, 1992, 48, 6, 1039-1052. https://www.sciencedirect.com/science/article/pii/S0040402001882004

5)            “Synthesis of Some Conformationally Restricted Serotonin Analogs,” John E. Macor* and Kevin Ryan, Heterocycles, 1990, 31, 8, 1497-1504. https://pubs.acs.org/doi/abs/10.1021/jm00163a062

4)            “Synthesis of [3H]CP-93,129: A  Radioligand Selective for the 5-HT1B Receptor,” John E. Macor,* Kevin Ryan, Phillip M. Chalabi, James C. Windels, and Robert W. Roth, Journal of Labelled Compounds and Radiopharmaceuticals, 1990 Vol.XXVIII, No.11, 1293. https://onlinelibrary.wiley.com/doi/abs/10.1002/jlcr.2580281109

3)            “3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: A Potent and Selective Serotonin (5HT1B) Agonist and Rotationally Restricted Phenolic Analog of 5-Methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole,” John E. Macor,* Carol A. Burkhart, James H. Heym, Jeffrey L. Ives, Lorraine A. Lebel, Michael E. Newman, Jann A. Nielsen, Kevin Ryan, David W. Schulz, Leslie K. Torgersen, and B. Kenneth Koe, Journal of Medicinal Chemistry, 1990, 33, 2087-2093. https://www.ncbi.nlm.nih.gov/pubmed/2374139

2)            “Synthesis of Pyrano[4,3-b]indoles as Conformationally Restricted Analogues of the Serotonin Antagonist ICS 205-930 and as Precursors to 2-Vinylindoles,” John E. Macor,* Kevin Ryan, and Michael E. Newman, Journal of Organic Chemistry, 1989, 54, 20, 4785-4795. https://pubs.acs.org/doi/abs/10.1021/jo00281a018

1)            “A Simple Synthesis of 2-Vinylindoles,” John E. Macor,* Kevin Ryan and Michael E. Newman, Tetrahedron Letters,1989,30, 19, 2509-2512. https://www.sciencedirect.com/science/article/pii/S0040403901804378